:root {
    --green-900: #0a2e1a; --green-800: #0d3f24; --green-700: #14532d;
    --green-600: #166534; --green-500: #16a34a; --green-400: #22c55e;
    --green-300: #4ade80; --green-200: #86efac; --green-100: #dcfce7;
    --green-50: #f0fdf4; --teal: #0d9488; --teal-dark: #115e59;
    --red-alert: #dc2626; --red-bg: #fef2f2;
    --amber-alert: #d97706; --amber-bg: #fffbeb;
    --blue-bg: #eff6ff; --blue-700: #1d4ed8;
    --purple-bg: #faf5ff; --purple-700: #7e22ce;
    --gray-50: #f9fafb; --gray-100: #f3f4f6; --gray-200: #e5e7eb;
    --gray-500: #6b7280; --gray-700: #374151; --gray-900: #111827;
    --font-display: 'Playfair Display', Georgia, serif;
    --font-body: 'Source Sans 3', 'Segoe UI', sans-serif;
    --font-mono: 'JetBrains Mono', Menlo, monospace;
}
* { box-sizing: border-box; margin: 0; padding: 0; }
html { -webkit-font-smoothing: antialiased; }
body {
    font-family: var(--font-body); color: var(--gray-900);
    background: var(--gray-50); line-height: 1.55;
}
.page {
    max-width: 920px; margin: 0 auto; padding: 32px 48px;
    background: white; min-height: 100vh;
    box-shadow: 0 0 24px rgba(0,0,0,.04);
}
@media print {
    body { background: white; }
    .page { box-shadow: none; padding: 16mm; max-width: 100%; }
    @page { size: A4; margin: 12mm; }
    .no-print { display: none; }
    section { page-break-inside: avoid; }
}

/* Header */
.doc-header {
    border-bottom: 2px solid var(--green-700);
    padding-bottom: 18px; margin-bottom: 24px;
}
.doc-label {
    font-family: var(--font-mono); font-size: 11px; font-weight: 500;
    letter-spacing: 2px; text-transform: uppercase;
    color: var(--green-700); margin-bottom: 8px;
}
.doc-title {
    font-family: var(--font-display); font-size: 32px; line-height: 1.15;
    color: var(--green-900); margin-bottom: 6px;
}
.doc-sub {
    font-size: 14px; color: var(--gray-500);
    font-family: var(--font-mono);
}

/* Patient strip */
.patient-strip {
    background: var(--green-50); border-left: 4px solid var(--green-600);
    padding: 14px 18px; margin-bottom: 22px; border-radius: 4px;
}
.patient-strip .label {
    font-family: var(--font-mono); font-size: 10px; letter-spacing: 1px;
    text-transform: uppercase; color: var(--green-700); margin-bottom: 4px;
}
.patient-strip .value { font-size: 15px; color: var(--gray-900); }
.patient-meta-grid {
    display: grid; grid-template-columns: repeat(auto-fit, minmax(150px, 1fr));
    gap: 10px 16px; margin-top: 12px; padding-top: 12px;
    border-top: 1px solid rgba(20, 83, 45, .16);
}
.patient-meta-item { min-width: 0; }
.patient-meta-item .meta-label {
    display: block; font-family: var(--font-mono); font-size: 10px;
    letter-spacing: .6px; text-transform: uppercase; color: var(--green-700);
    margin-bottom: 2px;
}
.patient-meta-item .meta-value {
    display: block; font-size: 14px; color: var(--gray-900);
    overflow-wrap: anywhere;
}

/* Banner — diagnostic phase */
.banner {
    border-radius: 8px; padding: 16px 20px; margin-bottom: 22px;
    border-left: 4px solid; font-size: 14px; line-height: 1.55;
}
.banner--diagnostic {
    background: var(--amber-bg); border-color: var(--amber-alert);
    color: #92400e;
}
.banner--diagnostic strong { display: block; font-size: 15px; margin-bottom: 4px; }
.banner--info {
    background: var(--green-50); border-color: var(--green-500);
    color: var(--green-800);
}
.banner--alert {
    background: var(--red-bg); border-color: var(--red-alert);
    color: #991b1b;
}

/* Sections */
section { margin-bottom: 28px; }
h2 {
    font-family: var(--font-display); font-size: 22px; line-height: 1.2;
    color: var(--green-800); margin-bottom: 12px;
}
.section-sub {
    font-size: 13px; color: var(--gray-500); margin-bottom: 14px;
    font-family: var(--font-mono);
}
h3 {
    font-size: 14px; font-weight: 700; text-transform: uppercase;
    letter-spacing: 0.5px; margin: 18px 0 10px; color: var(--gray-700);
}

/* Tracks (treatment plan) */
.tracks { display: grid; grid-template-columns: 1fr 1fr; gap: 16px; }
.track {
    border: 1px solid var(--gray-200); border-radius: 10px; padding: 18px;
    background: white;
}
.track--default { border-left: 4px solid var(--green-600); }
.track--alternative { border-left: 4px solid var(--gray-500); }
.track--surveillance { border-left: 4px solid var(--teal); }
.track--palliative { border-left: 4px solid var(--purple-700); }
.track-head {
    display: flex; justify-content: space-between; align-items: baseline;
    margin-bottom: 8px;
}
.track-name { font-family: var(--font-display); font-size: 18px; }
.track-default-badge {
    background: var(--green-100); color: var(--green-700);
    font-size: 10px; padding: 2px 8px; border-radius: 4px;
    font-family: var(--font-mono); text-transform: uppercase;
}
.track dl { font-size: 13px; }
.track dt { font-weight: 700; color: var(--gray-700); margin-top: 8px; }
.track dd { color: var(--gray-700); margin-left: 0; }
.track ul { font-size: 13px; padding-left: 18px; }

/* Tables — workup steps, etc. */
.tbl { width: 100%; border-collapse: collapse; font-size: 13px; }
.tbl th {
    background: var(--green-700); color: white; padding: 8px 10px;
    text-align: left; font-size: 11px; letter-spacing: 0.5px;
    text-transform: uppercase; font-weight: 600;
}
.tbl td {
    padding: 8px 10px; border-bottom: 1px solid var(--gray-100);
    vertical-align: top; color: var(--gray-700);
}
.tbl tr:last-child td { border-bottom: none; }
.tbl tbody tr:nth-child(even) td { background: var(--gray-50); }

/* Badges */
.badge {
    display: inline-block; padding: 2px 7px; border-radius: 4px;
    font-size: 10px; font-weight: 600; font-family: var(--font-mono);
    text-transform: uppercase; letter-spacing: 0.3px;
}
.badge--required { background: var(--red-bg); color: #b91c1c; }
.badge--recommended { background: var(--blue-bg); color: var(--blue-700); }
.badge--optional { background: var(--gray-100); color: var(--gray-700); }
.badge--blocking { background: var(--red-bg); color: #b91c1c; }
.badge--default { background: var(--green-100); color: var(--green-700); }
.badge--lab { background: var(--blue-bg); color: var(--blue-700); }
.badge--imaging { background: var(--purple-bg); color: var(--purple-700); }
.badge--histology { background: var(--amber-bg); color: #92400e; }
.badge--consult { background: var(--gray-100); color: var(--gray-700); }
.badge--other { background: var(--gray-100); color: var(--gray-700); }

/* Per-test "Where to order" cell — pre-treatment investigations */
.lab-avail-cell { font-size: 12px; line-height: 1.5; }
.lab-chip {
    display: inline-block; padding: 1px 6px; border-radius: 3px;
    background: var(--blue-bg); color: var(--blue-700);
    font-family: var(--font-mono); font-size: 11px;
    text-decoration: none; white-space: nowrap;
}
a.lab-chip:hover { text-decoration: underline; }

/* Lists */
.role-list { list-style: none; padding: 0; }
.role-list li {
    padding: 10px 0; border-bottom: 1px dashed var(--gray-200);
}
.role-list li:last-child { border-bottom: none; }
.role-list .role-name { font-weight: 600; color: var(--gray-900); }
.role-list .role-reason {
    font-size: 13px; color: var(--gray-700); margin-top: 4px;
}
.role-list .role-questions {
    font-size: 12px; color: var(--gray-500); margin-top: 4px;
    font-family: var(--font-mono);
}

.q-list { list-style: none; padding: 0; }
.q-list li {
    padding: 12px 14px; margin-bottom: 8px;
    border-radius: 6px; background: var(--gray-50);
    border-left: 3px solid var(--gray-200);
}
.q-list li.blocking {
    border-left-color: var(--red-alert); background: var(--red-bg);
}
.q-list--featured {
    margin: 8px 0 18px;
}
.q-list--featured li {
    background: #fff;
    border: 1px solid var(--green-200);
    border-left: 4px solid var(--green-600);
    box-shadow: 0 4px 14px rgba(6, 78, 59, 0.06);
}
.q-list--featured li.blocking {
    border-color: var(--red-alert);
    border-left-color: var(--red-alert);
}
.q-list--featured .q-text {
    font-size: 15px;
    font-weight: 600;
}
.q-list .q-id {
    font-family: var(--font-mono); font-size: 11px;
    color: var(--gray-500); margin-bottom: 4px;
}
.q-list .q-text { font-size: 14px; color: var(--gray-900); margin-bottom: 4px; }
.q-list .q-rationale { font-size: 12px; color: var(--gray-700); font-style: italic; }
.q-list .q-owner {
    font-family: var(--font-mono); font-size: 11px;
    color: var(--green-700); margin-top: 4px;
}

/* MDT block */
.mdt {
    background: var(--green-50); border-radius: 10px; padding: 18px;
    margin-top: 14px;
}

/* Steps timeline (workup) */
.steps { padding-left: 0; list-style: none; }
.steps li {
    padding: 10px 0 10px 36px; position: relative;
    border-bottom: 1px solid var(--gray-100);
}
.steps li:last-child { border-bottom: none; }
.steps .step-num {
    position: absolute; left: 0; top: 12px; width: 24px; height: 24px;
    background: var(--green-600); color: white; border-radius: 50%;
    display: flex; align-items: center; justify-content: center;
    font-size: 11px; font-weight: 700; font-family: var(--font-mono);
}
.steps .step-name { font-weight: 600; color: var(--gray-900); }
.steps .step-rationale { font-size: 12px; color: var(--gray-500); margin-top: 4px; }

/* Sources */
.sources { font-family: var(--font-mono); font-size: 11px; color: var(--gray-500); }
.sources li { padding: 4px 0; }

/* Etiological driver — featured card for etiologically_driven archetype */
.etiology-card {
    background: linear-gradient(135deg, var(--green-50) 0%, white 100%);
    border-left: 4px solid var(--teal); border-radius: 8px;
    padding: 18px 20px; margin-bottom: 22px;
}
.etiology-card .label {
    font-family: var(--font-mono); font-size: 11px; letter-spacing: 1px;
    text-transform: uppercase; color: var(--teal-dark); margin-bottom: 6px;
}
.etiology-card .archetype {
    font-family: var(--font-display); font-size: 18px; color: var(--green-900);
    margin-bottom: 8px;
}
.etiology-card ul { padding-left: 20px; font-size: 14px; color: var(--gray-700); }
.etiology-card ul li { padding: 3px 0; }

/* PRO/CONTRA — two-column grid for red flags */
.pro-contra { display: grid; grid-template-columns: 1fr 1fr; gap: 16px; }
.pc-col { border: 1px solid var(--gray-200); border-radius: 8px; padding: 14px; }
.pc-col--pro { border-left: 4px solid var(--amber-alert); background: var(--amber-bg); }
.pc-col--contra { border-left: 4px solid var(--red-alert); background: var(--red-bg); }
.pc-col h3 { color: var(--gray-900); margin-top: 0; }
.pc-col ul { padding-left: 20px; font-size: 13px; color: var(--gray-700); }
.pc-col li { padding: 4px 0; }
.pc-col .rf-id {
    font-family: var(--font-mono); font-size: 10px; color: var(--gray-500);
    display: block; margin-top: 2px;
}
a.rf-id, .rf-id-link {
    color: inherit; text-decoration: none;
}
a.rf-id:hover, .rf-id-link:hover {
    text-decoration: underline; color: var(--gray-700);
}
.pc-col .rf-note {
    font-size: 12px; color: var(--gray-600); line-height: 1.5;
    margin-top: 4px; padding-left: 8px; border-left: 2px solid var(--gray-200);
}
.pc-col .rf-src-row { display: block; margin-top: 3px; }
.pc-col .rf-src-chip {
    font-family: var(--font-mono); font-size: 9.5px;
    background: var(--gray-100); color: var(--gray-700);
    padding: 1px 6px; border-radius: 3px; margin-right: 4px;
    display: inline-block;
}
/* Severity hint via ::marker — no extra layout cost. Critical pops red,
   minor dims, major (default) keeps the inherited bullet color. */
.pc-col li[data-severity="critical"]::marker { color: var(--red-alert); font-weight: 800; }
.pc-col li[data-severity="minor"]::marker    { color: var(--gray-400); }

/* Branch-explanation — actually-fired RFs from the engine trace, with
   the conflict-resolution winner highlighted. Distinct from PRO/CONTRA
   above (which lists possible triggers in the abstract). */
.branch-explanation { margin: 18px 0; }
.branch-explanation .branch-step {
    background: var(--green-bg, #ecfdf5); border-left: 4px solid var(--green-700, #047857);
    padding: 10px 14px; border-radius: 6px; margin-bottom: 10px;
}
.branch-explanation .branch-step-head {
    font-size: 13px; color: var(--gray-700); margin-bottom: 6px; font-weight: 600;
}
.branch-explanation .branch-step ul {
    margin: 0; padding-left: 20px; font-size: 13px; color: var(--gray-700);
}
.branch-explanation .branch-step li { padding: 3px 0; line-height: 1.5; }
.branch-explanation .rf-winner-tag {
    font-family: var(--font-mono); font-size: 9.5px; letter-spacing: 0.5px;
    background: var(--green-700, #047857); color: white;
    padding: 1px 6px; border-radius: 3px; margin-left: 4px; vertical-align: 1px;
}
.branch-explanation .src-chip {
    font-family: var(--font-mono); font-size: 9.5px;
    background: var(--gray-100); color: var(--gray-700);
    padding: 1px 6px; border-radius: 3px; margin-left: 4px;
}

/* Do-not — strongly framed prohibitive list */
.do-not {
    background: var(--red-bg); border-left: 4px solid var(--red-alert);
    border-radius: 6px; padding: 14px 18px; margin-bottom: 12px;
}
.do-not .track-name {
    font-family: var(--font-display); font-size: 15px; color: var(--gray-900);
    margin-bottom: 8px;
}
.do-not ul { padding-left: 20px; font-size: 13px; color: #7f1d1d; }
.do-not li { padding: 3px 0; }

/* Timeline — horizontal phase strip */
.timeline {
    display: flex; gap: 4px; margin-top: 8px;
    overflow-x: auto; padding-bottom: 8px;
}
.tl-phase {
    flex: 1; min-width: 120px;
    background: var(--green-100); border-radius: 6px;
    padding: 10px 12px; border-top: 3px solid var(--green-600);
}
.tl-phase--baseline { border-top-color: var(--teal); background: #ccfbf1; }
.tl-phase--induction { border-top-color: var(--green-600); background: var(--green-100); }
.tl-phase--response { border-top-color: var(--amber-alert); background: var(--amber-bg); }
.tl-phase--maintenance { border-top-color: var(--blue-700); background: var(--blue-bg); }
.tl-phase--followup { border-top-color: var(--gray-500); background: var(--gray-100); }
.tl-phase .name {
    font-weight: 700; font-size: 12px; color: var(--gray-900);
    margin-bottom: 4px;
}
.tl-phase .window {
    font-family: var(--font-mono); font-size: 10px; color: var(--gray-700);
}

/* Footer */
.doc-footer {
    margin-top: 40px; padding-top: 20px;
    border-top: 1px solid var(--gray-200);
    font-size: 11px; color: var(--gray-500); line-height: 1.6;
}
.fda-disclosure {
    background: var(--gray-50); padding: 14px; border-radius: 6px;
    margin-bottom: 14px; font-size: 12px; color: var(--gray-700);
}
.fda-disclosure strong { color: var(--gray-900); }
.version-chain {
    font-family: var(--font-mono); font-size: 11px;
    background: var(--gray-100); padding: 8px 12px; border-radius: 4px;
    margin-bottom: 10px;
}
.medical-disclaimer {
    font-style: italic; color: var(--gray-700); font-size: 11px;
    border-left: 2px solid var(--gray-200); padding-left: 12px;
}

/* Skill catalog block */
.skill-catalog {
    margin-top: 18px;
    border-top: 1px dashed var(--green-200);
    padding-top: 10px;
}
.skill-catalog summary {
    cursor: pointer;
    color: var(--gray-700);
    font-size: 13px;
    font-weight: 600;
}
.skill-catalog table { width: 100%; border-collapse: collapse; font-size: 12px; }
.skill-catalog th {
    text-align: left; padding: 6px 8px; background: var(--gray-100);
    font-family: var(--font-mono); font-size: 10px; letter-spacing: 0.5px;
    text-transform: uppercase; color: var(--gray-700);
}
.skill-catalog td {
    padding: 6px 8px; border-bottom: 1px solid var(--gray-100);
    vertical-align: top;
}
.skill-catalog tr.activated td:first-child::before {
    content: "✓ "; color: var(--green-600); font-weight: 700;
}
.skill-catalog tr.dormant { color: var(--gray-500); }
.skill-catalog tr.dormant td:first-child::before {
    content: "○ "; color: var(--gray-500);
}
.skill-catalog .ver {
    font-family: var(--font-mono); color: var(--gray-700);
}

/* Access Matrix (ua-ingestion plan §4) */
.access-matrix { margin-top: 32px; padding: 20px; background: var(--green-50);
    border: 1px solid var(--green-200); border-radius: 6px;
}
.access-matrix details { width: 100%; }
.access-matrix summary {
    cursor: pointer; list-style: none; display: flex; flex-direction: column;
    gap: 4px; padding: 4px 0;
}
.access-matrix summary::-webkit-details-marker { display: none; }
.access-matrix summary::before {
    content: "▶ "; color: var(--green-700); font-size: 12px; margin-right: 4px;
}
.access-matrix details[open] summary::before { content: "▼ "; }
.access-matrix summary h2 {
    display: inline; font-family: var(--font-display); font-size: 22px;
    color: var(--green-900); margin: 0;
}
.access-matrix .section-sub { font-size: 12px; color: var(--gray-700); }
.access-matrix-table {
    width: 100%; border-collapse: collapse; margin-top: 14px;
    font-size: 12.5px; background: white;
}
.access-matrix-table th {
    text-align: left; padding: 8px 10px; background: var(--green-100);
    font-family: var(--font-mono); font-size: 10px; letter-spacing: 0.5px;
    text-transform: uppercase; color: var(--green-700);
    border-bottom: 1px solid var(--green-200);
}
.access-matrix-table td {
    padding: 10px; border-bottom: 1px solid var(--gray-100);
    vertical-align: top;
}
.access-matrix-table tr:last-child td { border-bottom: none; }
.access-matrix-table .track-cell { width: 32%; }
.access-matrix-table .regimen-name {
    font-size: 11.5px; color: var(--gray-700); margin-top: 3px;
}
.access-matrix-table .regimen-id {
    font-family: var(--font-mono); font-size: 10px; color: var(--gray-500);
}
.access-matrix-table .cost-cell { width: 22%; font-variant-numeric: tabular-nums; }
.access-matrix-table .cost-row { line-height: 1.5; }
.access-matrix-table .cost-label {
    font-family: var(--font-mono); font-size: 10px; color: var(--gray-500);
    margin-right: 4px;
}
.access-matrix-table .cost-trial {
    color: var(--green-700); font-style: italic;
}
.access-matrix-table .cost-unknown {
    color: var(--amber-alert); font-style: italic;
}
.access-matrix-table .pathway-cell { width: 22%; font-size: 11.5px; }
.access-matrix-table .pathway-cell .alt-paths {
    font-size: 10px; color: var(--gray-500);
}
.access-matrix-table .badge--ok { background: var(--green-100); color: var(--green-700); }
.access-matrix-table .badge--no { background: var(--red-bg); color: var(--red-alert); }
.access-matrix-table .badge--unknown { background: var(--gray-100); color: var(--gray-500); }
.access-matrix-table .badge {
    display: inline-block; padding: 2px 8px; border-radius: 3px;
    font-family: var(--font-mono); font-size: 10px; letter-spacing: 0.3px;
    white-space: nowrap;
}
.access-matrix-table tr.track-trial { background: var(--purple-bg); }
.access-matrix-table .notes {
    font-size: 11px; color: var(--gray-700); margin-top: 4px; font-style: italic;
}
.access-matrix-table .notes-stale {
    font-size: 11px; color: var(--amber-alert); margin-top: 4px; font-weight: 600;
}
.access-matrix-table .more-notes {
    cursor: help; color: var(--gray-500); font-size: 10px; margin-left: 4px;
    border-bottom: 1px dotted var(--gray-500);
}
.access-matrix .matrix-disclaimer {
    margin-top: 10px; font-size: 11px; color: var(--gray-500); font-style: italic;
}
.access-matrix .matrix-plan-notes {
    margin: 10px 0 4px 0; padding: 8px 12px; background: var(--amber-bg);
    border-left: 3px solid var(--amber-alert); list-style: none; font-size: 12px;
    color: var(--gray-900);
}
@media print {
    .access-matrix { background: white; border: 1px solid var(--gray-200); }
    .access-matrix details { width: 100%; }
    .access-matrix summary::before { content: ""; }
    .access-matrix details:not([open]) > *:not(summary) { display: block; }
}

/* Variant actionability — ESCAT tier badges */
.variant-actionability { margin: 22px 0; }
.variant-actionability h2 { color: var(--green-800); }
.variant-actionability .section-sub {
    font-size: 12px; color: var(--gray-500); margin-bottom: 10px;
    font-family: var(--font-mono);
}
.actionability-table {
    width: 100%; border-collapse: collapse; font-size: 12.5px;
    background: white; border: 1px solid var(--gray-200); border-radius: 6px;
    overflow: hidden;
}
.actionability-table th {
    text-align: left; padding: 8px 10px; background: var(--green-700); color: white;
    font-family: var(--font-mono); font-size: 10px; letter-spacing: 0.5px;
    text-transform: uppercase; font-weight: 600;
}
.actionability-table td {
    padding: 8px 10px; border-bottom: 1px solid var(--gray-100);
    vertical-align: top; color: var(--gray-700);
}
.actionability-table tr:last-child td { border-bottom: none; }
.actionability-table tbody tr:nth-child(even) td { background: var(--gray-50); }
.actionability-table .gene { font-family: var(--font-mono); font-weight: 600; color: var(--gray-900); }
.actionability-table .variant { font-family: var(--font-mono); color: var(--gray-700); }
.actionability-table .summary { font-size: 12px; color: var(--gray-700); }
.actionability-table .combos { font-size: 12px; color: var(--gray-700); }
.actionability-table .src-list {
    font-family: var(--font-mono); font-size: 10.5px; color: var(--gray-500);
}
.actionability-table .src-list li { padding: 1px 0; list-style: none; }
.actionability-table .empty-row td {
    text-align: center; color: var(--gray-500); font-style: italic;
    padding: 14px 10px;
}

/* Tier badges — ESCAT (IA/IB green; IIA/IIB yellow; IIIA/IIIB orange;
   IV light gray; X gray). Per-source level details render via
   .evidence-sources <ul> in the same row. */
.tier-badge {
    display: inline-block; padding: 2px 8px; border-radius: 4px;
    font-family: var(--font-mono); font-size: 11px; font-weight: 700;
    letter-spacing: 0.4px; white-space: nowrap;
}
.escat-IA, .escat-IB { background: #16a34a; color: white; }
.escat-IIA, .escat-IIB { background: #facc15; color: #713f12; }
.escat-IIIA, .escat-IIIB { background: #f97316; color: white; }
.escat-IC, .escat-IVA, .escat-IVB, .escat-IV { background: var(--gray-100); color: var(--gray-700); }
.escat-V { background: #e5e7eb; color: #7c2d12; }
.escat-X { background: var(--gray-200); color: var(--gray-700); }
.actionability-review-badge {
    display: block; width: fit-content; margin: 0 0 4px 0; padding: 2px 5px;
    border-radius: 3px; background: #fef3c7; color: #92400e;
    font-family: var(--font-mono); font-size: 9px; font-weight: 600;
}

/* Per-source evidence list inside each actionability row */
.evidence-sources {
    list-style: none; padding-left: 0; margin: 0;
    font-family: var(--font-mono); font-size: 11px;
}
.evidence-sources li { padding: 1px 0; color: var(--gray-700); }

/* Biomarker audit sub-sections (covered / uncovered split) */
.biomarker-subsection { margin-bottom: 10px; }
.biomarker-subsection-header {
    font-size: 12px; font-weight: 600; padding: 5px 0 4px 0;
    font-family: var(--font-mono); letter-spacing: 0.3px;
}
.biomarker-subsection.covered .biomarker-subsection-header { color: var(--green-700); }
.biomarker-subsection.uncovered .biomarker-subsection-header { color: #b45309; }
.uncovered-table th { background: #78716c; }
.biomarker-status-negative {
    display: inline-block; padding: 2px 8px; border-radius: 4px;
    background: var(--gray-100); color: var(--gray-600);
    font-family: var(--font-mono); font-size: 11px;
}
.biomarker-status-bio_exists {
    display: inline-block; padding: 2px 8px; border-radius: 4px;
    background: #dbeafe; color: #1e40af;
    font-family: var(--font-mono); font-size: 11px;
}
.biomarker-status-unmatched {
    display: inline-block; padding: 2px 8px; border-radius: 4px;
    background: #fef3c7; color: #92400e;
    font-family: var(--font-mono); font-size: 11px; font-weight: 600;
}
.evidence-sources .evidence-meta { color: var(--gray-500); font-size: 10px; }
.evidence-sources a { color: var(--green-700); text-decoration: none; }
.evidence-sources a:hover { text-decoration: underline; }

/* Resistance evidence flag — ⚠ badge for direction="Does Not Support"
   or significance contains "Resistance" (CIViC anti-evidence). */
.evidence-resistance {
    display: inline-block; padding: 0 6px; margin-left: 4px;
    border-radius: 3px;
    background: #fee2e2; color: #991b1b;
    font-size: 10px; font-weight: 700; letter-spacing: 0.3px;
}

/* Fallback rendering — when leveled evidence is unavailable,
   primary_sources are promoted as citation cards without a level.
   Visually muted relative to leveled evidence. */
.evidence-sources--fallback li.evidence-fallback {
    color: var(--gray-600); font-style: italic;
}
.evidence-fallback-note {
    margin-top: 4px;
    font-size: 10px; color: var(--gray-500);
    font-family: var(--font-sans); font-style: italic;
}

/* NSZU availability badges — per-drug coverage flag rendered alongside
   each component in the track's drug list. Render-time metadata only
   (engine never reads these — CHARTER §8.3 invariant). */
.nszu-badge {
    display: inline-block; padding: 2px 8px; border-radius: 4px;
    font-size: 0.85em; font-weight: 600; white-space: nowrap;
    margin-left: 6px; vertical-align: middle;
}
.nszu-covered { background: #d4edda; color: #155724; }
.nszu-partial { background: #fff3cd; color: #856404; }
.nszu-oop { background: #ffe5cc; color: #804000; }
.nszu-not-registered { background: #f8d7da; color: #721c24; }

/* ── Sign-off badges (CHARTER §6.1) ──────────────────────────────
   Surfaces Clinical Co-Lead approval state on each track in the
   treatment Plan render. Emitted by render._render_signoff_badge.
   Mirrored in docs/style.css for the static-site renderer. */
.track-signoff { margin: 4px 0 8px 0; }
.signoff-badge {
    display: inline-block; padding: 4px 10px; border-radius: 4px;
    font-size: 0.85em; font-weight: 600; line-height: 1.3;
    border: 1px solid transparent;
}
.signoff-pending {
    background: #fef2f2; color: #991b1b; border-color: #fecaca;
}
.signoff-partial {
    background: #fffbeb; color: #92400e; border-color: #fde68a;
}
.signoff-complete {
    background: #ecfdf5; color: #065f46; border-color: #a7f3d0;
}

.drug-list { list-style: none; padding-left: 0; margin: 4px 0; }
.drug-list .drug-row { padding: 3px 0; line-height: 1.5; }
.drug-list .drug-name { font-weight: 600; }
.drug-list .drug-id { font-family: var(--font-mono); font-size: 11px; color: var(--gray-500); }
.drug-list .drug-dose { color: var(--gray-700); font-size: 12px; margin-left: 4px; }

/* Treatment phases — multi-phase regimen rendering (PR2 of phases-refactor).
   Each phase is a discrete block with its own heading + drug list. Legacy
   auto-wrapped single-phase regimens (name="main") render the wrapper but
   suppress the heading, keeping the visual close to pre-PR2 for unmigrated
   YAMLs. Multi-phase regimens (lymphodepletion → main_infusion for axi-cel,
   etc.) render as visually separated blocks per
   docs/reviews/regimen-phases-refactor-plan-2026-04-28.md §4.4. */
.phase-block {
    border: 1px solid var(--gray-200); border-radius: 6px;
    padding: 10px 14px; margin-bottom: 8px; background: var(--gray-50);
}
.phase-block:last-child { margin-bottom: 4px; }
.phase-block[data-phase="main"]:only-of-type {
    /* Auto-wrapped legacy regimen — single block, no border noise. */
    border: none; padding: 0; background: transparent;
}
.phase-block .phase-heading {
    font-family: var(--font-mono); font-size: 11px;
    text-transform: uppercase; letter-spacing: 0.5px;
    color: var(--green-700); margin: 0 0 6px 0; font-weight: 700;
}
.phase-block .drug-list { margin: 0; }

/* Bridging options block — CAR-T / TIL manufacturing-window slot. Lists
   acceptable bridging regimen IDs; rendered after all phase blocks. */
.bridging-options {
    margin-top: 10px; padding: 10px 14px; background: var(--blue-bg);
    border-left: 3px solid var(--blue-700); border-radius: 4px;
}
.bridging-options .bridging-options-label {
    font-size: 12px; color: var(--blue-700);
    font-weight: 600; margin-bottom: 4px;
}
.bridging-options-list {
    list-style: none; padding-left: 0; margin: 0;
    font-family: var(--font-mono); font-size: 11px; color: var(--gray-700);
}
.bridging-options-list li.bridging-option { padding: 2px 0; }

/* PR5 — citation-presence guard
   `.no-citation-badge` is the WARN-mode flag rendered inline at the top of
   any Regimen / Indication / BMA cell whose declared sources fail to
   resolve to a real Source entity. It uses a soft amber palette so it
   reads as a warning without overpowering surrounding clinical content.
   `.stripped-block` is the STRICT-mode placeholder that replaces the
   block body when the same condition fires.

   Source: docs/reviews/cross-repo-task_torrent-sync-plan-2026-04-28.md
   §6 verifier algorithms — item #1 "Cite-or-strip at render". */
.no-citation-badge {
  display: inline-block;
  background: #fff8e1;
  color: #6d4c00;
  border: 1px solid #ffd54f;
  padding: 2px 6px;
  border-radius: 4px;
  font-size: 0.85em;
  margin: 4px 0;
}
.stripped-block {
  background: #fafafa;
  border: 1px dashed #bbb;
  color: #888;
  padding: 8px;
  font-style: italic;
  text-align: center;
}