Clinical Gap Audit

Generated 2026-05-13T10:02:19Z. This page tracks the largest remaining clinical-coverage gaps. It is a maintainer audit, not clinical guidance.

Gap	Current	Target	Status
Clinical sign-off	15/1930 signoff-eligible entities reviewed (0.8%)	>=85% reviewed before public guideline-grade claims	`blocked_on_reviewers`
Solid tumor 2L+ coverage	23/42 solid diseases have a 2L+ algorithm; 24/42 have a 2L+ indication	Every modeled solid disease has at least one advanced/relapsed-line algorithm and indication.	`coverage_gap`
Surgery/radiation detail	structured surgery entities: no; structured radiation entities: no; 424 indications mention surgery/radiation in text	Dedicated modality entities for surgery and radiation with dose/fraction/intent/timing fields.	`schema_gap`
Supportive-care depth	135/370 regimens have mandatory supportive care (36.5%); 43 have monitoring; 327 have dose adjustments	Every active regimen has supportive care, monitoring, dose-adjustment, and patient-watchpoint coverage.	`coverage_gap`
Drug indication and off-label tracking	812 drug-disease-indication pairs inferred from regimens; 0 carry explicit labeled/off-label status	Every drug-use pair has explicit regulatory-label status, NCCN/ESMO category, and source provenance.	`schema_gap`

blocked_on_reviewers

Current: 15/1930 signoff-eligible entities reviewed (0.8%)

Blocker: Cannot be fixed by code; requires qualified Clinical Co-Lead review.

Next: Batch the largest STUB queues by entity type and assign reviewer owners.

coverage_gap

Current: 23/42 solid diseases have a 2L+ algorithm; 24/42 have a 2L+ indication

Blocker: Missing disease-by-disease 2L+ algorithm/indication authoring queue.

Next: Prioritize missing high-volume solid diseases, then rare solid diseases.

schema_gap

Current: structured surgery entities: no; structured radiation entities: no; 424 indications mention surgery/radiation in text

Blocker: Current KB carries surgery/radiation mostly as prose inside indications.

Next: Add modality schemas first; migrate prose mentions after clinical review.

coverage_gap

Current: 135/370 regimens have mandatory supportive care (36.5%); 43 have monitoring; 327 have dose adjustments

Blocker: Supportive-care records exist, but regimen attachment is incomplete.

Next: Audit high-toxicity regimens first, then fill missing regimen attachments.

schema_gap

Current: 812 drug-disease-indication pairs inferred from regimens; 0 carry explicit labeled/off-label status

Blocker: No first-class drug_indications entity directory/schema is present.

Next: Introduce a drug_indications entity, then backfill from existing indications/regimens.

Detailed JSON and Markdown are published under /audits/clinical_gap_audit.json and /audits/clinical_gap_audit.md.